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The downregulation of ILF3 resulted in decreased expression of SLC7A11/GPX4 via the DEPTOR/mTOR signaling pathway, which induced ferroptosis

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Then using a H 2 O 2 -induced senescent TM3 Leydig cell model, we found that FOXO4 maintains the viability of senescent Leydig cells and that the FOXO4 blocker FOXO4-DRI induces apoptosis in these senescent cells