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In addition, we consider the role of functional polymorphisms in the human GPX1 gene on GPx1 expression and activity, and provide an update on the potential relationship between these polymorphisms and disease risk

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It comes out that if melatonin has a positive effect on granulosa cells, it decreases androgen production and enhances heme oxygenase-1 expression, which gives a direct reflection of the benefits for oocyte quality and also helps in oxidative stress issues [187]