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While DAMGO triggers MOR internalization by recruiting either arrestin 2 or 3, morphine selectively interacts with arrestin 3 which is recruited at the plasma membrane to promote MOR internalization (Groer et al., 2011)

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A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2