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The actions of betaine involve the accelerated turnover of the methionine-homocysteine cycle (i.e., one-carbon metabolism/folate cycle), where betaine is a substrate in the betaine-homocysteine S-methyltransferase (BHMT) reaction, which converts homocysteine to the essential reducing compound, methionine (Ueland et al., 2005

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4 This enabled administration of a sulfonamide antibiotic to treat an acute infection, but it did not clarify whether an allergic or anaphylactic potential was present