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Reference: Hsieh et al., 2017 (VEGFR2–Akt–eNOS signalling involvement) VEGFR2 activation triggers: VEGF binding → VEGFR2 autophosphorylation (turns on VEGFR2) which leads to → PI3K activation which leads to → Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis – more nitric oxide

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Efficient drug delivery by novel cell-penetrating peptide derived from Midkine, with two heparin binding sites braced by a length-specific helix