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Conclusions In summary, our study identifies microglial GLS1 as a central driver of PND pathogenesis, linking surgical stress‑induced neuroinflammation to neuronal ferroptosis via the STAT1–GLS1–glutamate–system Xc - signaling cascade

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While this review highlights various immunomodulatory functions of avian erythrocytes, the comprehensive scope of their involvement in avian immune responses remains to be fully elucidated