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Morphine-6-glucuronide is pcol active N-acetyl procainamide is pcol active GSH conjugates of haloalkenes are nephrotoxic via -lyase Acyl glucuronides are reactive, binding covalently to proteins• Of 52 pcol active metabolites in a 1985 review, only two were conjugates and those were acetylated products (Sutfin and Jusko, in Drug Metabolism and Disposition: Considerations in Clinical Pharmacology, Wilkinson and Rawlins, ed