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Research suggests that litchi pericarp polysaccharide (LPPs) can alter the cell wall integrity and membrane permeability of Staphylococcus aureus , leading to the leakage of intracellular macromolecules and small molecules, and inhibiting cell respiration and oxidative metabolism ( Escherichia coli proliferation by interfering with glycolysis and gluconeogenesis ( Microbial metabolites, especially SCFAs, play a crucial regulatory role in the pathogenesis and treatment of RA ( Faecalibacterium prausnitzii and Roseburia is significantly reduced in RA patients ( Beyond SCFAs, TCMPs also modulate various other microbiota-related metabolites, such as SAM, GGC, amino acid derivatives, and lipid metabolites